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A series of derivatives of dihydrofuran-2(3H)-one (γ-butyrolactone, GBL) was synthesized and tested for anticonvulsant, neurotoxic and analgesic activity. In the anticonvulsant screening 10 lactones were effective in the maximal electroshock test (MES) at the highest doses (300 and 100mg/kg, 0.5h, ip, mice). Statistical analysis showed correlation between the anticonvulsant activity and relative lipophilicity...
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