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A series of 1H-benzo[d]imidazole analogues of Pimobendan, substituted at position 5 with either –CF 3 or –NO 2 , were synthesized using a short synthetic route. All the nitro derivatives were potent, and exhibited a concentration- and partial endothelium-dependent vasorelaxant effects, with EC 50 s <5μM. 2-Methoxy-4-[5-nitro-1H-benzo[d]imidazol-2-yl]phenol (compound 13)...
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