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The extracellular haem‐binding protein from Streptomyces reticuli (HbpS) has been shown to be involved in redox sensing and to bind haem. However, the residues involved in haem coordination are unknown. Structural alignments to distantly related haem‐binding proteins from Mycobacterium tuberculosis were used to identify a candidate haem‐coordinating residue, and site‐directed mutagenesis with UV/Vis...
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