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A cDNA clone encoding an inwardly-rectifying K-channel (BIR1) was isolated from insulinoma cells. The predicted amino acid sequence shares 72% identity with the cardiac ATP-sensitive K-channel rcK ATP (K ATP -1; [6]). The mRNA is expressed in the brain and insulinoma cells. Heterologous expression inXenopus oocytes produced currents which were K + -selective,...
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