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It has been indicated that prostaglandin E 2 (PGE 2 ) and the receptor for PGE 2 (EP receptor) are key factors contributing to the facilitated generation of nociception. This study was designed to investigate the roles of PGE 2 and EP 1 receptors in the spinal cord in the nociceptive transmission, using behavioral and intracellular calcium ion concentration...
In order to try to gain a better understanding of the mechanisms of post-operative pain, this study was designed to psychophysically determine physiological and pharmacological characteristics of experimental pain induced by a 4-mm-long incision through the skin, fascia and muscle in the volar forearm of humans. In experiment 1, the subjects (n=8) were administered lidocaine systemically (a bolus...
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