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Emerging biologic and epidemiologic evidence suggests benefits of insulin-like growth factor-I (IGF-I) in cognitive aging.To examine the relation of circulating IGF-I to cognition.We measured plasma IGF-I and IGF-binding protein-3 (IGFBP-3) in 590 women aged 60–68 years. An average 10 years later, we administered telephone-based tests of general cognition (Telephone Interview of Cognitive Status [TICS]),...
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