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It has been suggested that uric acid acts as a peroxynitrite scavenger although it may also stimulate lipid peroxidation. To gain insight into how uric acid may act as an antioxidant, we used electron spin resonance to study the reaction of uric acid and plasma antioxidants with ONOO − . Peroxynitrite reacted with typical plasma concentrations of urate 16-fold faster than with ascorbate and...
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