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The neuroprotective effect of l-kynurenine sulfate (KYN), a precursor of kynurenic acid (KYNA, a selective N-methyl-d-aspartate receptor antagonist), was studied. KYN (300 mg/kg i.p., applied daily for 5 days) appreciably decreased the number of injured pyramidal cells from 1850±100/mm 2 to 1000±300/mm 2 (p<0.001) in the CA1 region of the hippocampus in the four-vessel occlusion...
l-Kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-d-aspartate receptor inhibitors. In contrast with kynurenic acid, l-kynurenine is transported across the blood-brain barrier, and it may therefore come into consideration as a therapeutic agent in certain neurobiological disorders, e.g. ischaemia-induced events. The present study evaluated the...
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