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To assess the toxicity of copper nanoparticles (23.5nm) in vivo, LD 50 , morphological changes, pathological examinations and blood biochemical indexes of experimental mice are studied comparatively with micro-copper particles (17μm) and cupric ions (CuCl 2 ·2H 2 O). The LD 50 for the nano-, micro-copper particles and cupric ions exposed to mice via oral gavage are...
Oxidative stress is considered to be one of the important mechanisms involved in carcinogenesis. In our previous study, gadolinium endohedral metallofullerenol ([Gd@C 82 (OH) 22 ] n nanoparticles) have shown high inhibitory activity on hepatoma cell (H22) growth in mice. To explore the antioxidative functions of nanoparticles, we investigated the biodistribution of [Gd@C ...
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