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Background
Meta‐analyses of randomized controlled trials (RCTs) have demonstrated the efficacy of vitamin D supplementation for reduced cancer mortality, all‐cause mortality, and respiratory tract infections. However, whether and to what extent this translates into effectiveness in real‐world practice is unknown.
Methods
We assessed the association of vitamin D supplement use (as an over‐the‐counter...
Background
Epidemiological studies consistently find low concentrations of 25‐hydroxyvitamin D (25(OH)D) in blood to be associated with increased mortality, and a recent large‐scale Mendelian randomization study strongly supports a causal relationship among individuals with low vitamin D status. Evolving evidence suggested that bioavailable or free 25(OH)D may better predict mortality. We aimed to...
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