The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The interleukin (IL)-1 superfamily of cytokines comprises a set of pivotal mediators of inflammation, playing an important role in innate and adaptive immune responses. Since the cloning of IL-1α and IL-1β, a number of additional members of this family have been discovered, including IL-18, IL-33, IL-36a, IL-36b, and IL-36g. While IL-1, IL-18 and IL-33 are well recognized for their immunomodulatory...
TNF is associated with the development of human immunopathologies and involved in host defense. TNF blockade to treat autoimmune inflammatory diseases revealed a crucial and non-redundant role of TNF for the control to tuberculosis infection. Tuberculosis is a chronic infection and sustained TNF and Th1 immune responses are crucial to control infection. To test and select specific human TNF inhibitors...
TNF is a pleiotropic cytokine associated with the development of human immunopathologies and involved in host defense mechanisms. TNF blockade has confirmed the crucial and non-redundant role of TNF in the control and resistance to tuberculosis infection. Most activities exerted by TNF were originally attributed to the soluble form of TNF (solTNF). The generation of uncleavable memTNF by mutations...
TNF plays an important role in host immunity to M. tuberculosis infection and contributes to granuloma formation. TNF inhibition has been shown to disorganize pulmonary granulomas and to reactivate tuberculosis in certain patients. Chemotherapy for tuberculosis requires long and difficult treatments with reduced patient compliance. To determine whether TNF inhibition can be an advantage for the efficacy...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.