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A robust cell‐responsive hydrogel photoresist, based on peptide‐crosslinked poly(vinyl alcohol), is demonstrated by Xiao‐Hua Qin and co‐workers in article number 1705564. This material enables spatiotemporal construction and manipulation of 3D cellular environments at micrometer‐scale resolution. By focusing a multiphoton laser, cell‐adhesive ligands are site‐specifically immobilized in a 3D matrix...
Advanced hydrogel systems that allow precise control of cells and their 3D microenvironments are needed in tissue engineering, disease modeling, and drug screening. Multiphoton lithography (MPL) allows true 3D microfabrication of complex objects, but its biological application requires a cell‐compatible hydrogel resist that is sufficiently photosensitive, cell‐degradable, and permissive to support...
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