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[2‐(2‐Aminopropoxy)‐1,3‐phenylene]dimethanol 1 and 4‐(2‐aminopropoxy)‐3‐(hydroxymethyl)‐5‐methylphenol 2, two dihydroxylated analogs of mexiletine – a well known class IB anti‐arrhythmic drug – were synthesized and used as pharmacological tools to investigate the blocking‐activity requirements of human skeletal muscle, voltage‐gated sodium channel. The very low blocking activity shown by newly synthesized...
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