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PEBBLEs (Probes Encapsulated By Biologically Localized Embedding) are sub-micron sized optical sensors specifically designed for minimally invasive analyte monitoring in viable, single cells with applications for real time analysis of drug, toxin, and environmental effects on cell function. PEBBLE nanosensor is a general term that describes a family of matrices and nano-fabrication techniques used...
AbstractWhat may be the smallest anthropogenic devices to date, spherical sensors (wireless and fiberless) with radii as small as 10nm have been produced. This class of optochemical PEBBLE (Probe Encapsulated By Biologically Localized Embedding) sensors covers a wide range of analytes (pH, calcium, oxygen and potassium included here) with excellent spatial, temporal and chemical resolution. Examples...
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