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BackgroundRadiation‐induced salivary hypofunction is a common side‐effect of treatment for head and neck cancers. Patients suffer significant morbidity and there is no suitable conventional therapy. We are conducting a Phase I clinical trial, using a first‐generation serotype 5 adenoviral (Ad5) vector encoding human aquaporin‐1 (AdhAQP1) to treat such patients. One week after the administration of...
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