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We employ stable‐isotope labeling and quantitative mass spectrometry to track histone methylation stability. We show that H3 trimethyl K9 and K27 are slow to be established on new histones and slow to disappear from old histones, with half‐lives of multiple cell divisions. By contrast, the transcription‐associated marks K4me3 and K36me3 turn over far more rapidly, with half‐lives of 6.8 h and 57 h,...
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