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Alcohol use disorder (AUD) is a complex psychiatric disorder with strong genetic and environmental risk factors. We studied the molecular perturbations underlying risky drinking behavior by measuring transcriptome changes across the neurocircuitry of addiction in a genetic mouse model of binge drinking. Sixteen generations of selective breeding for high blood alcohol levels after a binge drinking...
Platycladus orientalis (L.) is used extensively for afforestation and is a common medicinal ingredient. Because of its drought tolerance, P. orientalis is widely used for afforestation in arid and semi-arid areas. To better understand the mechanisms involved in drought-stress tolerance in this important tree, the transcriptome profiles of drought-treated P. orientalis seedlings were analyzed...
This paper proposes a two-phase feature selection method specific for bioinformatics domain from classification perspective in data mining. In the first phase, Bhattacharyya distance measurement is used for filtering the majority of irrelevant genes. Upon the basis, we apply floating sequential search method (FSSM) to further select informative gene set using kernel distance as measurement of class...
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