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Inflammation and immunity play an intrinsic role in the pathogenesis of NR-AS. Neopterin is mainly produced by activated macrophages.We examined serum neopterin levels in 51 patients undergoing valve replacement surgery [37 NR-AS and 14 aortic regurgitation (AR)].Serum neopterin levels were significantly higher in patients with NR-AS than in those with AR and age matched controls, whereas serum high-sensitivity...
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