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Lithium inhibition of glycogen synthase kinase3 (GSK3) activity has been shown to mimic the canonical WNT signaling. Analogous to WNT, lithium prevents GSK3-mediated phosphorylation of cytosolic transcription factor β-catenin and its subsequent degradation by the proteasome complex. Although stabilization of β-catenin in osteoblasts has been shown to promote bone mass accrual in a mouse model, several...
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