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Introduction. The INK4a-ARF [CDKN2A]- locus on chromosome 9p21 encodes for two tumour suppressor proteins, p16INK4a and p14ARF, which act as upstream regulators of the Rb-CDK4 and p53 pathways. To study the contribution of each pathway to the carcinogenesis of Barretts adenocarcinoma, we analysed the alterations of p14ARFand p16INK4a in preneoplastic and neoplastic lesions of this disease. Materials...
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