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Schizophrenia is likely to be a consequence of serial alterations of a number of genes and proteins that, together with environmental factors, will lead to the establishment of the illness. The comparative proteomic analysis of human brain tissue from schizophrenia patients and healthy controls using methods as two-dimensional gel electrophoresis and shotgun mass spectrometry may lead to the identification...
Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport,...
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