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Aims/hypothesis Recently, FTO was identified as a candidate gene contributing to both childhood and severe adult obesity. We tested the hypothesis that mRNA expression of FTO and/or of the neighbouring RPGRIP1L in adipose tissue correlates with measures of obesity and fat distribution. We also investigated whether the FTO obesity risk alleles might explain variability in FTO and RPGRIP1L mRNA expression...
Viszerale Adipositas ist ein unabhängiger Risikofaktor für die Entstehung kardiovaskulärer Erkrankungen und des Typ-2-Diabetes. Diesem Zusammenhang liegen sehr wahrscheinlich biologische Eigenschaften des viszeralen Fettgewebes zugrunde, die es grundlegend vom subkutanen Fettgewebe unterscheiden. Dabei spielt die anatomische Lokalisation des viszeralen Fettgewebes eine besondere Rolle, da Metaboliten...
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