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The stress inducible heat shock protein 70 (Hsp70) is present specifically on the tumour cell surface yet without a pro-tumour function revealed. We show here that cell surface localised Hsp70 (sHsp70) supports clathrin-independent endocytosis (CIE) in melanoma models. Remarkably, ability of Hsp70 to cluster on lipid rafts in vitro correlated with larger nano-domain sizes of sHsp70 in high sHsp70...
The stress inducible heat shock protein 70 (Hsp70) is present specifically on the tumour cell surface yet without a pro‐tumour function revealed. We show here that cell surface localised Hsp70 (sHsp70) supports clathrin‐independent endocytosis (CIE) in melanoma models. Remarkably, ability of Hsp70 to cluster on lipid raftsin vitro correlated with larger nano‐domain sizes of sHsp70 in high sHsp70 expressing...
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