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The study was designed to investigate the effect of nimesulide on lipopolysaccharide (LPS)-induced proinflammatory oxidants production by rat alveolar macrophages (AMs). Effects of LPS and nimesulide on antioxidant defense and the expression of inducible nitric oxide synthase (iNOS) were also studied. It was found that nimesulide could scavenge superoxide anions (O 2− ), nitric oxide...
Nitric oxide is thought to be an important modulator of various functions in normal and inflamed airways. In the present study, we evaluated the effects of high vitamin E (250 mg and 1250 mg α-tocopheryl acetate (TA)/kg diet/10 days) on nitric oxide (NO) release by alveolar macrophages (AMs) in response to lipopolysaccharide (LPS), interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α). LPS and...
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