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Mineralocorticoid receptor (MR) is a ligand-dependent transcription factor involved in gene regulation in association with another corticosteroid receptor, glucocorticoid receptor. In the absence of ligand, MR resides both in the cytoplasm and in the nucleus. Agonists increase the number of MRs residing in the nucleus. Importins are docking proteins for karyopherin-mediated binding of substrate in...
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