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To develop a PET imaging agent to visualize brain cholinergic neurons and synaptic changes caused by Alzheimer's disease, (−)‐ and (+)‐o‐[11C]methyl‐trans‐decalinvesamicol ([11C]OMDV) were isolated and investigated for differences in not only their binding affinity and selectivity to vesicular acetylcholine transporter (VAChT), but also their in vivo activities. [11C]OMDV has a high binding affinity...
We investigated the characteristics of the regional rat brain distribution of radio‐brominated o‐bromo‐decalinvesamicol (OBDV) in vivo to evaluate its potential as a PET ligand for vesicular acetylcholine transporter (VAChT). In in vivo biodistribution study, the specific brain regional accumulation of [77Br]OBDV was revealed 30 min after intravenous injection. The specific brain regional accumulation...
In this study, the regional rat brain distribution of radioiodinated o‐iodo‐trans‐decalinvesamicol ([125I]OIDV) was determined in vivo to evaluate its potential as a single‐photon emission computed tomography (SPECT) imaging probe for vesicular acetylcholine transporter (VAChT). Following intravenous injection, [125I]OIDV passed freely across the blood–brain barrier and accumulated in rat brain. The...
Flash lamp annealing (FLA), with millisecond‐order duration, can crystallize amorphous silicon (a‐Si) films a few μm thick on glass substrates, resulting in formation of polycrystalline Si (poly‐Si) films with unprecedented periodic microstructures. The characteristic microstructure, formed spontaneously during crystallization, consists of large‐grain regions, containing relatively large grains more...
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