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ObjectiveTo investigate the costimulatory role of Crry/p65 (Crry), a membrane complement regulatory protein, on the expansion and function of natural Treg cells and their ability to ameliorate proteoglycan‐induced arthritis (PGIA), an animal model of inflammatory arthritis in which the role of natural Treg cells is not well established.
MethodsCD4+CD25+ natural Treg cells from BALB/c mice were activated...
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