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Computer-aided design (CAD) for synthetic biology has been proposed to parallel similar efforts in other engineering disciplines, such as electrical engineering or mechanical engineering. However, there is an important distinction between the fields, which is that the mechanisms by which biological systems function are not currently fully understood in sufficient detail to make completely predictive...
In electronic computing, high-level languages hide much of the details, allowing non-experts and sometimes even children to program and create systems. High level languages for biomolecular systems aim to achieve a similar level of abstraction, so that a system might be designed on the basis of the behaviors that are desired, rather than the particulars of the genetic code that will be used to implement...
This book is devoted to the design and analysis of biomolecular circuits as considered in systems biology and synthetic biology. The aim of the book is to present in a coherent framework some of the most recent work on the analysis, simulation and design of biomolecular circuits and systems, reflecting the interdisciplinary and collaborative nature of the field. The results discussed range from how...
Automatic design of synthetic gene networks with specific functions is an emerging field in synthetic biology. Quantitative evaluation of gene network designs is a missing feature of the existing automatic design tools. In this work, we address this issue and present a framework to probabilistically analyze the dynamic behavior of a gene network against specifications given in a rich and high level...
MoClo Planner is an interactive visualization system for collaborative bio-design, utilizing a multi-touch interactive surface. The system integrates the information gathering, design, and specification of complex synthetic biological constructs using the Modular Cloning (MoClo) assembly method. Modular Cloning is a hierarchical DNA construction method that allows for the assembly of multi-part constructs...
We present a framework that allows us to construct and formally analyze the behavior of synthetic gene circuits from specifications in a high level language used in describing electronic circuits. Our back-end synthesis tool automatically generates genetic-regulatory network (GRN) topology realizing the specifications with assigned biological “parts” from a database. We describe experimental procedures...
With the growing complexity of synthetic biological circuits, robust and systematic methods are needed for design and test. Leveraging lessons learned from the semiconductor and design automation industries, synthetic biologists are starting to adopt computer-aided design and verification software with some success. However, due to the great challenges associated with designing synthetic biological...
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