Search results for: William L. Klein
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Constitutive Alzheimer's-Type Tau Epitopes in a Neuritogenic Rat CNS Cell Line
Neurobiology of Aging > 1995 > 16 > 4 > 583-589
Paired helical filaments (PHFs) of Alzheimer's disease (AD) largely comprise hyperphosphorylated forms of the cytoskeletal protein tau. AD-type tau phosphoepitopes, detected by various monoclonal antibodies, are absent from normal adult neurons, but recent studies have shown that their expression may contribute to neuritogenesis and axon differentiation in the developing nervous system. Therefore,...
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