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The menopause is associated with an increased incidence of atherosclerotic disease. Estrogen deficiency causes AT1 receptor overexpression which is involved in the development of vascular dysfunction.The effect of a 6 week-treatment with the AT1 receptor antagonist candesartan (16mg/d) on endothelium-dependent vasorelaxation was compared to the treatment with placebo or the calcium channel antagonist...
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