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The brain is particularly enriched in glycerophospholipids with either arachidonic or docosahexaenoic acid esterified in the stereospecifically numbered-2 position. In this paper, we review how combining a kinetic approach to study the uptake and turnover of arachidonic and docosahexaenoic acids within brain phospholipids of unanesthetized rats, along with chronic administration of antimanic drugs...
Rationale Fluoxetine is used to treat unipolar depression and is thought to act by increasing the concentration of serotonin (5-HT) in the synaptic cleft, leading to increased serotonin signaling. The 5-HT2A/2C receptor subtypes are coupled to a phospholipase A2 (PLA2). We hypothesized that chronic fluoxetine would increase the brain activity of PLA2 and the turnover rate of arachidonic acid (AA)...
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