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Most loci discovered through genome-wide association analyses are predicted to affect gene expression, the integrative approach of genome-wide analysis with gene expression data is becoming essential procedure for discovering genetic effect of disease development. Many studies have been performed to discover significant SNP-gene associations, but most of them are limited to consider only cis-associations...
A multi-electrode array (MEA) is a micro-fabricated cell culture dish with embedded microelectrodes at the bottom of the dish. Recently MEAs with different cell-adhesive patterns are actively used to analyze behaviors of in vitro neural systems. It is difficult to confirm the underlying anatomical synaptic connections of the in vitro neural networks based on neural recordings from MEAs. Meanwhile,...
Reverse engineering of gene regulatory networks from microarray time series data has been a challenging problem due to the limit of available data. In this paper, a new approach is proposed based on the concept of transfer entropy. Using this information theoretic measure, causal relations between pairs of genes are assessed to draw a causal network. A heuristic rule is then applied to differentiate...
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