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Inflammation is a major contributor to neuronal injury and is associated with poor outcome after acute brain injury such as stroke. The pro‐inflammatory cytokine interleukin (IL)‐1 is a critical regulator of cerebrovascular inflammation after ischemic injury, mainly through action of both of its isoforms, IL‐1α and IL‐1β, at the brain endothelium. In contrast, the differential action of these ligands...
J. Neurochem. (2011) 119, 760–771.
AbstractTwo of the main stresses faced by cells at the neurovascular unit (NVU) as an immediate result of cerebral ischemia are oxygen–glucose deprivation (OGD)/reperfusion and inflammatory stress caused by up regulation of IL‐1. As a result of these stresses, perlecan, an important component of the NVU extracellular matrix, is highly proteolyzed. In this study,...
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