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Interleukin-1 (IL-1) is a pro-inflammatory cytokine that plays an important role in inflammatory responses to injury and infection, both, systemically and within the central nervous system. There are two IL-1 ligands, IL-1α and IL-1β, which bind to the interleukin 1 receptor type I (IL-1RI) activating multiple pathways that lead to the expression of acute phase and pro-inflammatory proteins. Although...
Interleukin (IL)-1 is a pivotal pro-inflammatory cytokine and an important mediator of both acute and chronic central nervous system (CNS) injuries. Despite intense research in CNS IL-1 biology over the past two decades, its precise mechanism of action in inflammatory responses to acute brain disorders remains largely unknown. In particular, much effort has been focussed on using in vitro approaches...
The putative new interleukin (IL)-1 family member IL-1F8 (IL-1η, IL-1H2) has been shown recently to activate mitogen activated protein kinases (MAPKs), extracellular signal-regulated protein kinase (ERK1/2) and c-Jun N-terminal kinase (JNK), and nuclear factor-kappa B (NFκB) via a mechanism that requires IL-1Rrp2 expression in cell lines. The aim of this study was to test the hypothesis that IL-1F8...
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