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AimsTo investigate the role of the mucosa in (−)‐isoprenaline‐induced relaxation of mouse detrusor muscle and to characterize the β‐adrenoceptor subtypes involved.
MethodsIsolated intact and mucosa‐denuded muscle strips from the urinary bladder of male C57BL6 mice were pre‐contracted with KCl (40 mM) and were relaxed with increasing concentrations of the β‐adrenoceptor (β‐AR) agonist (−)‐isoprenaline...
ObjectivesTo elucidate the impact of the mucosa on detrusor muscle function by investigating force of contraction under various stimulatory conditions and during subsequent relaxation using catecholamines.
Patients and MethodsDetrusor tissue was obtained from patients who had undergone cystectomy for bladder cancer and strips of intact or mucosa‐denuded muscle were set up for force measurement....
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