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Objective To demonstrate that increased formation of reactive oxygen (ROS) and nitrogen species (RNS) is involved in VILI-induced vascular dysfunction. Methods Male Sprague-Dawley anesthetized rats were ventilated for 60 min using low VT ventilation [VT 9 ml/kg, positive end-expiratory pressure (PEEP) 5 cmH2O, n = 18], and high VT ventilation (VT 35 ml/kg, zero PEEP, n = 18). Arterial pressure and...
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