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Objective To test the hypothesis that aging increases the susceptibility to organ dysfunction and systemic inflammation induced by injurious mechanical ventilation. Design and setting Experimental study in an animal model of ventilator-induced lung injury in the animal research laboratory in a university hospital. Methods Young (3–4 months old) and old (22–24 months old) anesthetized Wistar rats...
Objective To describe the time course of the changes in pulmonary and vascular function, and systemic inflammation induced by injurious mechanical ventilation. Design Experimental study in an animal model of ventilator-induced lung injury. Setting Animal research laboratory. Methods Anesthetized male adult Sprague-Dawley rats were ventilated with VT 9 ml/kg and PEEP 5 cm H2O, or VT 35 ml/kg...
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