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The hormonal form of vitamin D, 1α,25(OH)2-vitaminD3 [1α,25(OH)2D3], stimulates signal transduction pathways in intestinal cells. To gain insight into the relative importance of the vitamin D receptor (VDR) in the rapid hormone responses, the amounts and localization of the VDR were evaluated in young (3 months) and aged (24 months) rat intestinal cells. Immune-fluorescence and Western blot studies...
In intestinal cells, 1α,25(OH)2-vitamin D3 (1α,25(OH)2D3) regulates gene expression via the specific intracellular vitamin D receptor and induces fast non-transcriptional responses involving stimulation of transmembrane signal transduction pathways. In the present study, we analyzed, for the first time, alterations in p38 MAPK response to 1α,25(OH)2D3 in rat enterocytes with ageing. In enterocytes...
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