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NanoCluster Beacons (NCBs) are multicolor silver nanocluster probes whose fluorescence can be activated or tuned by a proximal DNA strand called the activator. While a single‐nucleotide difference in a pair of activators can lead to drastically different activation outcomes, termed polar opposite twins (POTs), it is difficult to discover new POT‐NCBs using the conventional low‐throughput characterization...
Fluorescent Nanomaterials
By repurposing next‐generation sequencing chips, millions of fluorescent NanoCluster Beacons (NCBs) can be screened in a single experiment. Combining this high‐throughput screening platform with machine‐learning algorithms, in article number 2204957, Hsin‐Chih Yeh and co‐workers establish a pipeline to design bright and multicolor NCBs in silico.
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