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Background Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis, a characteristic feature of pancreatic cancer. Although it is still controversial, previous studies have suggested that PSCs promote the progression of pancreatic cancer by regulating the cell functions of cancer cells. PSCs produce large amounts of IL-6, which promotes the accumulation of myeloid-derived suppressor...
AimEpithelial–mesenchymal transition (EMT) is a crucial process during cancer invasion and metastasis, which is accompanied by the suppressed expression of E‐cadherin initiated by stimuli such as transforming growth factor (TGF)‐β. Recent studies have shown that the epigenetic regulation of E‐cadherin could be an alternate mechanism of EMT induction in hepatocellular carcinoma (HCC). miRNA‐29a (miR‐29a)...
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