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Purpose We have previously shown that high molecular weight (MW > 100 kDa) chitosan nanocapsules are efficient vehicles for improving the oral absorption of salmon calcitonin (sCT). In the present work, our objectives were, first, to investigate the influence of some formulation parameters on the efficacy of chitosan nanocapsules as carriers for the oral administration of sCT and, second, to elucidate...
Positively charged colloidal drug carriers have shown interesting properties with respect to the negatively charged systems: they have improved stability in the presence of biological cations and their interaction with negatively charged biological membranes is facilitated. In the present work, a new approach in order to provide a positive charge to colloidal systems, i.e., poly-ɛ-caprolactone (PECL)...
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