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AbstractNovel glutathione (GSH) analogs, previously shown to inhibit glutathione S-transferase (GST) activity at about 1M in vitro, were tested for their ability to potentiate the killing of cultured tumor cells by chemotherapeutic drugs. When tested at doses up to 200M, the analogs were neither toxic nor capable of potentiating drug toxicity unless the diethyl ester (DEE) form was used for treatment...
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