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The regulation of muscle contraction by calcium involves interactions among actin filaments, myosin-S1, tropomyosin (Tm), and troponin (Tn). We have extended our previous model in which the TmTn regulatory units are treated as a continuous flexible chain, and applied it to transient kinetic data. We have measured the time course of myosin-S1 binding to actin-Tm-Tn filaments in solution at various...
The strain-dependent kinetics of the myosin working stroke under load is derived from a flat-energy-landscape model for its untethered lever-arm, and compared with other scenarios in the literature. The “flat landscape” scenario is compatible with muscle-fiber experiments, but is more critically relevant to single-myosin experiments with an optically trapped actin filament. In such experiments, the...
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