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J. Neurochem. (2012) 120, 741–751.
AbstractSynaptic remodeling has been postulated as a mechanism underlying synaptic plasticity and cell adhesion molecules are thought to contribute to this process. We examined the role of nectin‐1 ectodomain shedding on synaptogenesis in cultured rat hippocampal neurons. Nectins are Ca2+‐independent immunoglobulin‐like adhesion molecules, involved in cell‐cell...
J. Neurochem. (2011) 119, 945–956.
AbstractNectins play an important role in forming various intercellular junctions including synapses. This role is regulated by several secretases present at intercellular junctions. We have investigated presenilin (PS)‐dependent secretase‐mediated processing of nectins in PS1 KO cells and primary hippocampal neurons. The loss of PS1/γ‐secretase activity delayed...
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