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In article number 2007408, Lei Dong, Chunming Wang, and co‐workers invent a “bridge‐burning” bioactive coating to sequentially turn on and off inflammation on bone implants. This coating first instructs host macrophages to activate bone cells to promote healing and then receives signals from bone cells to kill macrophages for higher safety. It improves bone‐implant integration in mice with osteoporosis...
Osteoporosis poses substantial challenges for biomaterials implantation. New approaches to improve bone‐implant integration should resolve the fundamental dilemma of inflammation—proper inflammation is required at early stages but should be suppressed later for better healing, especially under osteoporosis. However, precisely switching on and off inflammation around implants in vivo remains unachieved...
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