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In studies on transversal slices of the rat dorsal hippocampus, we found that low-frequency tetanic stimulation of the medial perforant pathway (2 sec-1, 7.5 min) results in long-term depression (LTD) of field EPSP of granular cells in the dentate gyrus. This synaptic plasticity phenomenon was weakened by calmodulin, nitric oxide synthase, and protein kinase C inhibitors, trifluoperazine (1 μM), N-nitro-L-arginine...
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