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AbstractThe effect of intrapleural instillation of recombinant human interferon (IFN) at increasing doses of (112) 106 U was examined in six patients with cytologically positive pleural effusion due to lung cancer. Intrapleural instillation was repeated up to three times. Clinically, no reaccumulation of pleural effusion was observed in one patient and disappearance of lung cancer cells from the pleural...
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