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Rationale. Caffeine and nicotine are the main psychoactive ingredients of coffee and tobacco, respectively, with a high frequency of concurrent use in humans. Objectives. The aim of the present study was to examine the interaction of caffeine and nicotine in rats trained to discriminate nicotine from saline. Methods. Two groups of male Sprague-Dawley rats (n=8 per group) were trained to discriminate...
Rationale. A1 and A2A adenosine receptors are co-localized with dopamine D1 and D2 receptors, respectively, and their stimulation attenuates dopaminergic functioning. Objective. To test whether adenosine antagonists with different selectivities for A1 and A2A receptors mimic the discriminative-stimulus effects of dopamine releaser methamphetamine. Methods. Effects of the A1 antagonist DPCPX, the preferential...
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