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Increasing evidence demonstrates that different opioids, while acting μ opioid receptors, can activate distinct downstream responses, a phenomenon termed functional selectivity or biased agonism. The present study designed experiments to test whether the μ receptor agonist morphine and D-Ala 2 , N-Me-Phe 4 , Gly 5 -ol-enkephalin (DAMGO) had a different effect on presynaptic...
The effect of l-stepholidine (SPD), a novel alkaloid extract of the Chinese herb Stephania with partial dopamine D1 receptor agonistic and D2 receptor antagonistic dual actions, on morphine conditioned place preference (CPP) was studied. Daily injection of morphine (10mg/kg, i.p.) for 6days induced CPP in rats, and daily treatment with SPD at 10 or 20mg/kg before morphine injection dose-dependently...
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