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ASA404 (5,6‐dimethylxanthenone‐4‐acetic acid, vadimezan), a flavone‐8‐acetic acid analogue, is a novel tumor‐vascular disrupting agent. In this study, the safety and tolerability, pharmacokinetics and pharmacodynamics of ASA404 in combination with standard therapy of paclitaxel and carboplatin (P/C) were assessed. A total of 15 Japanese patients with stage IV advanced non‐small cell lung cancer were...
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